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Mouse Anti-POT1 Recombinant Antibody (M1-P1H5) (CBMAB-P2424-YC)

Provided herein is a Mouse monoclonal antibody against Human Protection Of Telomeres 1. The antibody can be used for immunoassay techniques, such as WB, ICC, IF.
See all POT1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
M1-P1H5
Antibody Isotype
IgG1, κ
Application
WB, ICC, IF

Basic Information

Immunogen
Peptide sequence-IPASEVLMDD
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Protection of Telomeres 1
Introduction
POT1 is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression.
Entrez Gene ID
25913
UniProt ID
Q9NUX5
Alternative Names
CMM10; GLM9; HPOT1
Function
Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity.
Biological Process
DNA duplex unwindingManual Assertion Based On ExperimentIDA:BHF-UCL
Establishment of protein localization to telomereManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of telomerase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of telomere maintenance via telomeraseManual Assertion Based On ExperimentIGI:BHF-UCL
Positive regulation of DNA helicase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of DNA strand elongationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of helicase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of telomerase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of telomere maintenance1 PublicationIC:ComplexPortal
Positive regulation of telomere maintenance via telomeraseManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of DNA helicase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of double-strand break repair via nonhomologous end joiningManual Assertion Based On ExperimentIDA:CACAO
Regulation of telomere maintenance via telomeraseManual Assertion Based On ExperimentIGI:BHF-UCL
Telomere assemblyManual Assertion Based On ExperimentIDA:BHF-UCL
Telomere cappingManual Assertion Based On ExperimentIDA:ComplexPortal
Telomere maintenance via telomeraseManual Assertion Based On ExperimentIDA:UniProtKB
Telomeric D-loop disassemblyManual Assertion Based On ExperimentIGI:BHF-UCL
Cellular Location
Nucleus
Chromosome, telomere
Colocalizes with telomeric DNA.
Involvement in disease
Melanoma, cutaneous malignant 10 (CMM10):
A malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites.
Glioma 9 (GLM9):
Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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