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Mouse Anti-POU4F3 Recombinant Antibody (CBLNP-190) (CBMAB-1679-CN)

This product is a mouse antibody that recognizes POU4F3 of human. The antibody CBLNP-190 can be used for immunoassay techniques such as: FC, IF, WB.
See all POU4F3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLNP-190
Antibody Isotype
IgG1
Application
FC, IF, WB

Basic Information

Immunogen
Recombinant fragment: PAALTSHPHH AVHQGLEGDL LEHISPTLSV SGLGAPEHSV MPAQIHPHHL GAMGHLHQAM GMSHPHTVAP HSAMPACLSD VESDPRELEA F, corresponding to aa. 100-191 of Human POU4F3
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
POU class 4 homeobox 3
Introduction
POU4F3 is a member of the POU-domain family of transcription factors which have been observed to play important roles in control of cell identity in several systems. Defects in this gene are the cause of non-syndromic sensorineural deafness autosomal dominant type 15. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons.
Entrez Gene ID
5459
UniProt ID
Q15319
Alternative Names
BRN3C; DFNA15; DFNA42; DFNA52
Function
Acts as a transcriptional activator (PubMed:18228599).
Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes (PubMed:18228599).
Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear (By similarity).
Biological Process
Axon extensionIEA:Ensembl
Inner ear auditory receptor cell differentiationIEA:Ensembl
Inner ear morphogenesisIEA:Ensembl
Neuromuscular process controlling balanceIEA:Ensembl
Neuron apoptotic processIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Retinal ganglion cell axon guidanceIEA:Ensembl
Sensory perception of soundManual Assertion Based On ExperimentTAS:ProtInc
Vestibulocochlear nerve developmentIEA:Ensembl
Visual perceptionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus
Cytoplasm
Preferentially localized in the nucleus.
Involvement in disease
Deafness, autosomal dominant, 15 (DFNA15):
A form of non-syndromic hearing loss with variable phenotype in terms of age at onset, levels of progression, and shape of audiograms.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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