Mouse Anti-PPCS Recombinant Antibody (7G13) (CBMAB-BR395LY)

Name: Mouse Anti-PPCS Recombinant Antibody (7G13)
SKU: CBMAB-BR395LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

7G13

Application

FC: 1-3 μg/1x10 cells, IHC-P: 0.5-1 μg/ml, WB: 0.1-0.5 μg/ml

Immunogen

A synthetic peptide corresponding to a sequence of human PPCS (VEIEEKIVDNLQSRHTAFIGDRN).

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2a

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Preservative

0.05 mg sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

phosphopantothenoylcysteine synthetase

Entrez Gene ID

Human	79717
Mouse	106564
Rat	298490

UniProt ID

Human	Q9HAB8
Mouse	Q8VDG5
Rat	D4A6X7

Alternative Names

Phosphopantothenate--cysteine ligase; Phosphopantothenoylcysteine synthetase; PPC synthetase

Function

Catalyzes the second step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine (PubMed:11923312, PubMed:12906824, PubMed:29754768).
Has a preference for ATP over CTP as a cosubstrate (PubMed:11923312).

Biological Process

Acetyl-CoA biosynthetic processManual Assertion Based On ExperimentIMP:UniProtKB
Coenzyme A biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Heart processManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

cytoplasm
cytosol
nucleus

Involvement in disease

Cardiomyopathy, dilated 2C (CMD2C):
A form of dilated cardiomyopathy, a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. CMD2C is an autosomal recessive form with variable severity and age of onset ranging from 2 to 20 years. Death in infancy or early childhood may occur in severely affected children.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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