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Mouse Anti-PPCS Recombinant Antibody (7G13) (CBMAB-BR395LY)

The product is antibody recognizes PPCS. The antibody 7G13 immunoassay techniques such as: FC, IHC-P, WB.
See all PPCS antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
7G13
Antibody Isotype
IgG2a
Application
FC: 1-3 μg/1x10 cells, IHC-P: 0.5-1 μg/ml, WB: 0.1-0.5 μg/ml

Basic Information

Immunogen
A synthetic peptide corresponding to a sequence of human PPCS (VEIEEKIVDNLQSRHTAFIGDRN).
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Preservative
0.05 mg sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
phosphopantothenoylcysteine synthetase
Entrez Gene ID
Human79717
Mouse106564
Rat298490
UniProt ID
HumanQ9HAB8
MouseQ8VDG5
RatD4A6X7
Alternative Names
Phosphopantothenate--cysteine ligase; Phosphopantothenoylcysteine synthetase; PPC synthetase
Function
Catalyzes the second step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine (PubMed:11923312, PubMed:12906824, PubMed:29754768).
Has a preference for ATP over CTP as a cosubstrate (PubMed:11923312).
Biological Process
Acetyl-CoA biosynthetic processManual Assertion Based On ExperimentIMP:UniProtKB
Coenzyme A biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Heart processManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
cytoplasm
cytosol
nucleus
Involvement in disease
Cardiomyopathy, dilated 2C (CMD2C):
A form of dilated cardiomyopathy, a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. CMD2C is an autosomal recessive form with variable severity and age of onset ranging from 2 to 20 years. Death in infancy or early childhood may occur in severely affected children.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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