Mouse Anti-PPM1B Recombinant Antibody (1A3-2A4) (CBMAB-P2554-YC)

Name: Mouse Anti-PPM1B Recombinant Antibody (1A3-2A4)
SKU: CBMAB-P2554-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1A3-2A4

Application

IF, WB

Immunogen

PPM1B (AAH12002, 1-193 aa) full length recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform

Introduction

PPM1B is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death.

Entrez Gene ID

5495

UniProt ID

O75688

Alternative Names

PP2C-beta-X; PP2CB; PPC2BETAX; PP2C-beta; PP2CBETA

Function

Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.

Biological Process

N-terminal protein myristoylationISS:UniProtKB
Negative regulation of defense response to virusManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of interferon-beta productionManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of NIK/NF-kappaB signalingManual Assertion Based On ExperimentIMP:UniProtKB
Peptidyl-threonine dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Protein dephosphorylationManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm, cytosol
Membrane
Weakly associates at the membrane and N-myristoylation mediates the membrane localization.

PTM

Isgylation negatively regulates its activity.
N-myristoylation is essential for the recognition of its substrates for dephosphorylation.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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