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Rabbit Anti-PPM1E Recombinant Antibody (CBYC-P555) (CBMAB-P2560-YC)

Provided herein is a Rabbit monoclonal antibody against Human Protein Phosphatase, Mg2+/Mn2+ Dependent 1E. The antibody can be used for immunoassay techniques, such as WB, IP, FC, ICC, IF.
See all PPM1E antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBYC-P555
Antibody Isotype
IgG
Application
WB, IP, FC, ICC, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Protein Phosphatase, Mg2+/Mn2+ Dependent 1E
Introduction
PPM1E is a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5'-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases.
Entrez Gene ID
22843
UniProt ID
Q8WY54
Alternative Names
AW049266; B930008A12Rik; POPX1; PP2CH; mKIAA1072
Function
Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity).
Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2 (By similarity).
Biological Process
Cellular response to xenobiotic stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of protein kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Peptidyl-threonine dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of stress fiber assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Cytoplasm
A truncated form, major form, with the C-terminal part missing, is mostly found in the cytoplasm and a little in the nucleus. The full-length, minor form, is found in the nucleus.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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