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Mouse Anti-PPP2R2B Recombinant Antibody (1B10) (CBMAB-P2634-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein Phosphatase 2 Regulatory Subunit Bbeta. The antibody can be used for immunoassay techniques, such as ELISA, IP.
See all PPP2R2B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1B10
Antibody Isotype
IgG2b, κ
Application
ELISA, IP

Basic Information

Immunogen
PPP2R2B (AAH31790, 1-444 aa) full length recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PPP2R2B
Introduction
PPP2R2B belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements.
Entrez Gene ID
5521
UniProt ID
Q00005
Alternative Names
PP2APR55B; SCA12; PP2APR55BETA; PR52B; PR2APR55BETA; PP2AB55BETA; PR2ABBETA; PR55-BETA; PP2ABBETA; B55BETA; PR2AB55BETA; PR55BETA
Function
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity (By similarity).
Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance (By similarity).
Biological Process
Apoptotic processIEA:UniProtKB-KW
Cellular Location
Isoform 1
Cytoplasm
Cytoplasm, cytoskeleton
Membrane
Isoform 2
Cytoplasm
Mitochondrion
Mitochondrion outer membrane
Under basal conditions, localizes to both cytosolic and mitochondrial compartments. Relocalizes from the cytosolic to the mitochondrial compartment during apoptosis. Its targeting to the outer mitochondrial membrane (OMM) involves an association with import receptors of the TOM complex and is required to promote proapoptotic activity (By similarity).
Involvement in disease
Spinocerebellar ataxia 12 (SCA12):
Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA12 is an autosomal dominant cerebellar ataxia (ADCA).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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