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Mouse Anti-PRG4 Recombinant Antibody (1D5) (CBMAB-P2773-YC)

Provided herein is a Mouse monoclonal antibody against Human PRG4 (Proteoglycan 4) is a Protein Coding gene. Diseases associated with PRG4 include Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome and Pericarditis. Among its related pathways are ERK Signaling and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include scavenger receptor activity and polysaccharide binding. An important paralog of this gene is VTN. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PRG4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1D5
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
proteoglycan 4
Introduction
PRG4 is a large proteoglycan that is synthesized by chondrocytes located at the surface of articular cartilage and by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid.
Entrez Gene ID
10216
UniProt ID
Q92954
Alternative Names
CACP; HAPO; JCAP; MSF; SZP
Function
Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface.
Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages.
Biological Process
Immune responseIEA:InterPro
Cellular Location
Secreted
Involvement in disease
Camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP):
An autosomal recessive disorder characterized by the association of congenital or early-onset camptodactyly and non-inflammatory arthropathy with synovial hyperplasia. Individuals with CACP have normal appearing joints at birth but with advancing age develop joint failure, non-inflammatory synoviocyte hyperplasia and subintimal fibrosis of the synovial capsule. Some patients also manifest progressive coxa vara deformity and/or non-inflammatory pericardial or pleural effusions.
PTM
N-glycosylated (PubMed:16335952).
O-glycosylated; contains glycosaminoglycan chondroitin sulfate and keratan sulfate. O-glycosylated with sialylated oligosaccharides which are predominantly represented by the monosialylated core type I structure, NeuNAcalpha2-3Galbeta1-3GalNAc, with smaller amounts of disialylated O-glycans (PubMed:25187573).
The disulfide bond between Cys-1146 and Cys-1403 is essential for protein cleavage.
Proteolytically cleaved by cathepsin CTSG.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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