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Mouse Anti-PRKAR2B Recombinant Antibody (RS17) (CBMAB-P2817-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein kinase cAMP-dependent type II regulatory subunit beta. The antibody can be used for immunoassay techniques, such as ELISA, ICC, IF.
See all PRKAR2B antibodies

Summary

Host Animal
Mouse
Specificity
Human, Pig, Cattle
Clone
RS17
Antibody Isotype
IgG2a
Application
ELISA, ICC, IF

Basic Information

Immunogen
purified regulatory subunit of cAMP-dependent protein kinase type II from bovine brain
Specificity
Human, Pig, Cattle
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Protein kinase cAMP-dependent type II regulatory subunit beta
Introduction
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity.
Entrez Gene ID
Human5577
Pig110262251
Cattle282463
UniProt ID
HumanP31323
PigA0A286ZNQ7
CattleP31322
Alternative Names
PRKAR2; RII-BETA
Function
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
Biological Process
Fatty acid metabolic processIEA:Ensembl
Intracellular signal transductionManual Assertion Based On ExperimentTAS:ProtInc
LearningIEA:Ensembl
Modulation of chemical synaptic transmissionIEA:Ensembl
Negative regulation of cAMP-dependent protein kinase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Response to antipsychotic drugIEA:Ensembl
Response to clozapineIEA:Ensembl
Cellular Location
Cytoplasm
Cell membrane
Colocalizes with PJA2 in the cytoplasm and at the cell membrane.
PTM
Phosphorylated by the activated catalytic chain.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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