Mouse Anti-PRKAR2B Recombinant Antibody (RS17) (CBMAB-P2817-YC)

Name: Mouse Anti-PRKAR2B Recombinant Antibody (RS17)
SKU: CBMAB-P2817-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

RS17

Application

ELISA, ICC, IF

Immunogen

purified regulatory subunit of cAMP-dependent protein kinase type II from bovine brain

Specificity

Human, Pig, Cattle

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Protein kinase cAMP-dependent type II regulatory subunit beta

Introduction

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity.

Entrez Gene ID

Human	5577
Pig	110262251
Cattle	282463

UniProt ID

Human	P31323
Pig	A0A286ZNQ7
Cattle	P31322

Alternative Names

PRKAR2; RII-BETA

Function

Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.

Biological Process

Fatty acid metabolic processIEA:Ensembl
Intracellular signal transductionManual Assertion Based On ExperimentTAS:ProtInc
LearningIEA:Ensembl
Modulation of chemical synaptic transmissionIEA:Ensembl
Negative regulation of cAMP-dependent protein kinase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Response to antipsychotic drugIEA:Ensembl
Response to clozapineIEA:Ensembl

Cellular Location

Cytoplasm
Cell membrane
Colocalizes with PJA2 in the cytoplasm and at the cell membrane.

PTM

Phosphorylated by the activated catalytic chain.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-PRKAR2B Recombinant Antibody (RS6) (CAT#: CBMAB-P2819-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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