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Mouse Anti-PRKG2 Recombinant Antibody (10D5) (CBMAB-P2882-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein Kinase CGMP-Dependent 2. The antibody can be used for immunoassay techniques, such as WB.
See all PRKG2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
10D5
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 40-320 of human PRKG2(NP_006250 produced in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Protein Kinase CGMP-Dependent 2
Introduction
PRKG2 (Protein Kinase CGMP-Dependent 2) is a protein coding gene. Diseases associated with PRKG2 include Chromosome 4Q21 Deletion Syndrome and Mast-Cell Sarcoma. Among its related pathways are NO-dependent CFTR activation (normal and CF) and Gap junction. Gene Ontology annotations related to this gene include protein homodimerization activity and protein kinase activity.
Entrez Gene ID
5593
UniProt ID
Q13237
Alternative Names
PRKGR2; cGK2; cGKII
Function
Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (PubMed:33106379).
Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity).
Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity).
Biological Process
Negative regulation of chloride transportIEA:Ensembl
Negative regulation of chondrocyte proliferationIEA:Ensembl
Peptidyl-serine autophosphorylationIEA:Ensembl
Protein localization to plasma membraneIEA:Ensembl
Protein phosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of chondrocyte differentiationIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIMP:UniProtKB
Tetrahydrobiopterin metabolic processTAS:Reactome
Cellular Location
Apical cell membrane
Involvement in disease
Spondylometaphyseal dysplasia, Pagnamenta type (SMDP):
A form of spondylometaphyseal dysplasia, a group of short stature disorders distinguished by abnormalities in the vertebrae and the metaphyses of the tubular bones. SMDP is an autosomal recessive form characterized by short stature and mild platyspondyly with no disproportion between the limbs. Mild metaphyseal changes are present.
Acromesomelic dysplasia 4 (AMD4):
A form of acromesomelic dysplasia, a skeletal disorder characterized by short stature, very short limbs and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers). AMD4 radiographic hallmarks include mild to moderate platyspondyly, moderate brachydactyly, iliac flaring, and metaphyseal alterations of the long bones that progressively increase with age. AMD4 inheritance is autosomal recessive.
PTM
Myristoylation mediates membrane localization.
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For research use only. Not intended for any clinical use.

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