Sign in or Register   Sign in or Register
  |  

Mouse Anti-PRKX Recombinant Antibody (1H7) (CBMAB-P2896-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein Kinase X-Linked. The antibody can be used for immunoassay techniques, such as ELISA, IP, WB.
See all PRKX antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1H7
Antibody Isotype
IgG2a, κ
Application
ELISA, IP, WB

Basic Information

Immunogen
PRKX (AAH41073, AA 269-358 partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
protein kinase, X-linked
Introduction
PRKX is a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation.
Entrez Gene ID
5613
UniProt ID
P51817
Alternative Names
PKX1; Pkare
Function
Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation.
Biological Process
AngiogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Cell adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Cell-substrate adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Endothelial cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Endothelial cell proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Epithelial tube morphogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Kidney morphogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Myeloid cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein autophosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell adhesionManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of epithelial cell differentiation involved in kidney developmentManual Assertion Based On ExperimentIDA:UniProtKB
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Nucleus
cAMP induces nuclear translocation.
Involvement in disease
A chromosomal aberration involving PRKX is a cause of sex reversal disorder. Translocation t(X;Y)(p22;p11) with PRKY. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sex reversal disorder in XX males and XY females.
PTM
Phosphorylated; autophosphorylates in vitro.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-PRKX Recombinant Antibody (1H7)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare