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Mouse Anti-PRPF31 Recombinant Antibody (8E1) (CBMAB-P3011-YC)

Provided herein is a Mouse monoclonal antibody against Human Pre-mRNA processing factor 31. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PRPF31 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
8E1
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae)
Introduction
PRPF31 is a component of the spliceosome complex and is one of several retinitis pigmentosa-causing genes. When the gene product is added to the spliceosome complex, activation occurs.
Entrez Gene ID
26121
UniProt ID
Q8WWY3
Alternative Names
U4/U6 SnRNP 61 KDa Protein; PRP31; NY-BR-99
Function
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11867543, PubMed:28781166).
Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:11867543).
Biological Process
mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Ribonucleoprotein complex localizationManual Assertion Based On ExperimentIMP:UniProtKB
Spliceosomal tri-snRNP complex assemblyManual Assertion Based On ExperimentIDA:MGI
Cellular Location
Nucleus
Nucleus speckle
Nucleus, Cajal body
Predominantly found in speckles and in Cajal bodies.
Involvement in disease
Retinitis pigmentosa 11 (RP11):
A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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