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Mouse Anti-PRPF6 Recombinant Antibody (B-1) (CBMAB-P3018-YC)

Provided herein is a Mouse monoclonal antibody against Human Pre-mRNA processing factor 6. The antibody can be used for immunoassay techniques, such as WB, IP, IF, IHC-P, ELISA.
See all PRPF6 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
B-1
Antibody Isotype
IgG
Application
WB, IP, IF, IHC-P, ELISA

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Pre-mRNA processing factor 6
Introduction
PRPF6 appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing.
Entrez Gene ID
Human24148
Mouse68879
Rat366276
UniProt ID
HumanO94906
MouseQ91YR7
RatA1A5S1
Alternative Names
ANT-1; ANT1; C20orf14; Prp6; RP60; SNRNP102; TOM; U5-102K; hPrp6
Function
Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:28781166, PubMed:21549338).
Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.
Biological Process
mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:MGI
RNA localizationManual Assertion Based On ExperimentIMP:MGI
RNA splicing1 PublicationNAS:UniProtKB
RNA splicing, via transesterification reactions1 PublicationNAS:UniProtKB
Spliceosomal complex assembly1 PublicationNAS:UniProtKB
Spliceosomal tri-snRNP complex assemblyManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular Location
Nucleus, nucleoplasm
Nucleus speckle
Localized in splicing speckles.
Involvement in disease
Retinitis pigmentosa 60 (RP60):
A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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