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Mouse Anti-PRRX1 Recombinant Antibody (1C2) (CBMAB-P3048-YC)

Provided herein is a Mouse monoclonal antibody against Human Paired Related Homeobox 1. The antibody can be used for immunoassay techniques, such as IHC-P, WB.
See all PRRX1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1C2
Antibody Isotype
IgG2a
Application
IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
paired related homeobox 1
Introduction
PRRX1 (Paired Related Homeobox 1) is a protein coding gene. Diseases associated with PRRX1 include Agnathia-Otocephaly Complex and Dysgnathia Complex. Gene Ontology annotations related to this gene include sequence-specific DNA binding and HMG box domain binding.
Entrez Gene ID
5396
UniProt ID
P54821
Alternative Names
AGOTC; PHOX1; PMX1; PRX-1; PRX1
Function
Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity).
Biological Process
Artery morphogenesisIEA:Ensembl
Cartilage developmentIEA:Ensembl
Embryonic cranial skeleton morphogenesisIEA:Ensembl
Biological Process embryonic limb morphogenesisIEA:Ensembl
Inner ear morphogenesisIEA:Ensembl
Mesenchymal cell proliferationIEA:Ensembl
Middle ear morphogenesisIEA:Ensembl
Neuron fate determinationIEA:Ensembl
Neuronal stem cell population maintenanceIEA:Ensembl
Positive regulation of DNA repair by transcription from RNA polymerase II promoterManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of mesenchymal cell proliferationIEA:Ensembl
Positive regulation of smoothened signaling pathwayIEA:Ensembl
Positive regulation of stem cell proliferationIEA:Ensembl
Regulation of neuron projection regenerationIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Roof of mouth developmentIEA:Ensembl
Smoothened signaling pathwayIEA:Ensembl
Stem cell proliferationIEA:Ensembl
Cellular Location
Nucleus
Involvement in disease
Agnathia-otocephaly complex (AGOTC):
A rare condition characterized by mandibular hypoplasia or agnathia, ventromedial auricular malposition (melotia) and/or auricular fusion (synotia), and microstomia with oroglossal hypoplasia or aglossia. Holoprosencephaly is the most commonly identified association, but skeletal, genitourinary, and cardiovascular anomalies, and situs inversus have been reported. The disorder is almost always lethal.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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