Mouse Anti-PRRX1 Recombinant Antibody (1C2) (CBMAB-P3048-YC)

Name: Mouse Anti-PRRX1 Recombinant Antibody (1C2)
SKU: CBMAB-P3048-YC
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

1C2

Application

IHC-P, WB

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

paired related homeobox 1

Introduction

PRRX1 (Paired Related Homeobox 1) is a protein coding gene. Diseases associated with PRRX1 include Agnathia-Otocephaly Complex and Dysgnathia Complex. Gene Ontology annotations related to this gene include sequence-specific DNA binding and HMG box domain binding.

Entrez Gene ID

5396

UniProt ID

P54821

Alternative Names

AGOTC; PHOX1; PMX1; PRX-1; PRX1

Function

Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity).

Biological Process

Artery morphogenesisIEA:Ensembl
Cartilage developmentIEA:Ensembl
Embryonic cranial skeleton morphogenesisIEA:Ensembl
Biological Process embryonic limb morphogenesisIEA:Ensembl
Inner ear morphogenesisIEA:Ensembl
Mesenchymal cell proliferationIEA:Ensembl
Middle ear morphogenesisIEA:Ensembl
Neuron fate determinationIEA:Ensembl
Neuronal stem cell population maintenanceIEA:Ensembl
Positive regulation of DNA repair by transcription from RNA polymerase II promoterManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of mesenchymal cell proliferationIEA:Ensembl
Positive regulation of smoothened signaling pathwayIEA:Ensembl
Positive regulation of stem cell proliferationIEA:Ensembl
Regulation of neuron projection regenerationIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Roof of mouth developmentIEA:Ensembl
Smoothened signaling pathwayIEA:Ensembl
Stem cell proliferationIEA:Ensembl

Cellular Location

Nucleus

Involvement in disease

Agnathia-otocephaly complex (AGOTC):
A rare condition characterized by mandibular hypoplasia or agnathia, ventromedial auricular malposition (melotia) and/or auricular fusion (synotia), and microstomia with oroglossal hypoplasia or aglossia. Holoprosencephaly is the most commonly identified association, but skeletal, genitourinary, and cardiovascular anomalies, and situs inversus have been reported. The disorder is almost always lethal.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-PRRX1 Recombinant Antibody (1E2) (CAT#: CBMAB-P3050-YC)

Mouse Anti-PRRX1 Recombinant Antibody (1E10) (CAT#: CBMAB-P3049-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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