Mouse Anti-PSEN2 Recombinant Antibody (APS 21) (CBMAB-0735CQ)

Name: Mouse Anti-PSEN2 Recombinant Antibody (APS 21)
SKU: CBMAB-0735CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

APS 21

Application

WB, IF, IHC-P, ELISA

Immunogen

Synthetic peptide from Human Presenilin 2 aa 31-45

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Presenilin 2

Introduction

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.

Entrez Gene ID

Human	5664
Mouse	19165
Rat	81751

UniProt ID

Human	P49810
Mouse	Q61144
Rat	O88777

Alternative Names

AD4; PS2; AD3L; STM2; CMD1V

Function

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed:16959576).
Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed:21285369).

Biological Process

Amyloid precursor protein catabolic processManual Assertion Based On ExperimentIDA:ARUK-UCL
Amyloid-beta formationManual Assertion Based On ExperimentIDA:ARUK-UCL
Amyloid-beta metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Calcium ion transportManual Assertion Based On ExperimentIBA:GO_Central
Intracellular signal transductionIEA:InterPro
Membrane protein ectodomain proteolysisManual Assertion Based On ExperimentIDA:HGNC-UCL
Mitochondrion-endoplasmic reticulum membrane tetheringManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of apoptotic processManual Assertion Based On ExperimentIBA:GO_Central
Notch receptor processingManual Assertion Based On ExperimentIBA:GO_Central
Notch signaling pathwayIEA:UniProtKB-KW
Positive regulation of catalytic activityManual Assertion Based On ExperimentIDA:HGNC-UCL
Protein processingManual Assertion Based On ExperimentIDA:HGNC-UCL
Regulation of calcium import into the mitochondrionManual Assertion Based On ExperimentIMP:UniProtKB
Response to hypoxiaIEA:Ensembl

Cellular Location

Endoplasmic reticulum membrane
Golgi apparatus membrane

Involvement in disease

Alzheimer disease 4 (AD4):
A familial early-onset form of Alzheimer disease. Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituents of these plaques are neurotoxic amyloid-beta protein 40 and amyloid-beta protein 42, that are produced by the proteolysis of the transmembrane APP protein. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products, such as C31, are also implicated in neuronal death.
Cardiomyopathy, dilated 1V (CMD1V):
A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.

Topology

Cytoplasmic: 1-87
Helical: 88-108
Lumenal: 109-138
Helical: 139-159
Cytoplasmic: 160-166
Helical: 167-187
Lumenal: 188-200
Helical: 201-221
Cytoplasmic: 222-223
Helical: 224-244
Lumenal: 245-249
Helical: 250-270
Cytoplasmic: 271-361
Helical: 362-382
Lumenal: 383-388
Helical: 389-409
Cytoplasmic: 410-413
Helical: 414-434
Lumenal: 435-448

PTM

Heterogeneous proteolytic processing generates N-terminal and C-terminal fragments.
Phosphorylated on serine residues.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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