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Mouse Anti-PSENEN Recombinant Antibody (12K165) (CBMAB-P3115-YC)

Provided herein is a Mouse monoclonal antibody against Human Presenilin enhancer gamma secretase subunit. The antibody can be used for immunoassay techniques, such as IHC.
See all PSENEN antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
12K165
Antibody Isotype
IgG
Application
IHC

Basic Information

Immunogen
Synthetic peptide corresponding to aa89-98 from human PSENEN
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 89-98

Target

Full Name
presenilin enhancer 2 homolog (C. elegans)
Introduction
PSENEN (Presenilin Enhancer, Gamma-Secretase Subunit) is a protein coding gene. Diseases associated with PSENEN include Acne Inversa, Familial, 2, With Or Without Dowling-Degos Disease and Dowling-Degos Disease. Among its related pathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and NOTCH2 Activation and Transmission of Signal to the Nucleus.
Entrez Gene ID
55851
UniProt ID
Q9NZ42
Alternative Names
MSTP064; PEN-2; MDS033; PEN2
Function
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111, PubMed:30598546, PubMed:30630874).
The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111).
Biological Process
Amyloid precursor protein catabolic processManual Assertion Based On ExperimentIDA:ComplexPortal
Amyloid precursor protein metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Amyloid-beta formationManual Assertion Based On ExperimentIMP:UniProtKB
Membrane protein ectodomain proteolysisManual Assertion Based On ExperimentIDA:HGNC-UCL
Membrane protein intracellular domain proteolysisManual Assertion Based On ExperimentIDA:ComplexPortal
Notch receptor processingManual Assertion Based On ExperimentIBA:GO_Central
Notch signaling pathwayIEA:UniProtKB-KW
Positive regulation of catalytic activityManual Assertion Based On ExperimentIDA:HGNC-UCL
Positive regulation of endopeptidase activityManual Assertion Based On ExperimentIMP:UniProtKB
Protein processingManual Assertion Based On ExperimentIDA:HGNC-UCL
Cellular Location
Endoplasmic reticulum membrane
Golgi apparatus, Golgi stack membrane
Cell membrane
Membrane
Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
Involvement in disease
Acne inversa, familial, 2, with or without Dowling-Degos disease (ACNINV2):
An autosomal dominant form of acne inversa, a chronic relapsing inflammatory disease of the hair follicles characterized by recurrent draining sinuses, painful skin abscesses, and disfiguring scars. Manifestations typically appear after puberty. Some ACNINV2 patients also exhibit reticulate hyperpigmentation consistent with Dowling-Degos disease.
Topology
Cytoplasmic: 1-17
Helical: 18-36
Cytoplasmic: 37-57
Helical: 58-78
Lumenal: 79-101
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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