Sign in or Register   Sign in or Register
  |  

Mouse Anti-PSENEN Recombinant Antibody (1C12-G5) (CBMAB-P3116-YC)

Provided herein is a Mouse monoclonal antibody against Human Presenilin enhancer, gamma-secretase subunit. The antibody can be used for immunoassay techniques, such as WB, IP, ELISA.
See all PSENEN antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1C12-G5
Antibody Isotype
IgG
Application
WB, IP, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
presenilin enhancer 2 homolog (C. elegans)
Introduction
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.
Entrez Gene ID
55851
UniProt ID
Q9NZ42
Alternative Names
MDS033; MSTP064; PEN-2; PEN2
Function
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111, PubMed:30598546, PubMed:30630874).
The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111).
Biological Process
Amyloid precursor protein catabolic processManual Assertion Based On ExperimentIDA:ComplexPortal
Amyloid precursor protein metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Amyloid-beta formationManual Assertion Based On ExperimentIMP:UniProtKB
Membrane protein ectodomain proteolysisManual Assertion Based On ExperimentIDA:HGNC-UCL
Membrane protein intracellular domain proteolysisManual Assertion Based On ExperimentIDA:ComplexPortal
Notch receptor processingManual Assertion Based On ExperimentIBA:GO_Central
Notch signaling pathwayIEA:UniProtKB-KW
Positive regulation of catalytic activityManual Assertion Based On ExperimentIDA:HGNC-UCL
Positive regulation of endopeptidase activityManual Assertion Based On ExperimentIMP:UniProtKB
Protein processingManual Assertion Based On ExperimentIDA:HGNC-UCL
Cellular Location
Endoplasmic reticulum membrane
Golgi apparatus, Golgi stack membrane
Cell membrane
Membrane
Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
Involvement in disease
Acne inversa, familial, 2, with or without Dowling-Degos disease (ACNINV2):
An autosomal dominant form of acne inversa, a chronic relapsing inflammatory disease of the hair follicles characterized by recurrent draining sinuses, painful skin abscesses, and disfiguring scars. Manifestations typically appear after puberty. Some ACNINV2 patients also exhibit reticulate hyperpigmentation consistent with Dowling-Degos disease.
Topology
Cytoplasmic: 1-17
Helical: 18-36
Cytoplasmic: 37-57
Helical: 58-78
Lumenal: 79-101
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-PSENEN Recombinant Antibody (1C12-G5)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare