Mouse Anti-PSENEN Recombinant Antibody (1C12-G5) (CBMAB-P3116-YC)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111).
Amyloid precursor protein metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Amyloid-beta formationManual Assertion Based On ExperimentIMP:UniProtKB
Membrane protein ectodomain proteolysisManual Assertion Based On ExperimentIDA:HGNC-UCL
Membrane protein intracellular domain proteolysisManual Assertion Based On ExperimentIDA:ComplexPortal
Notch receptor processingManual Assertion Based On ExperimentIBA:GO_Central
Notch signaling pathwayIEA:UniProtKB-KW
Positive regulation of catalytic activityManual Assertion Based On ExperimentIDA:HGNC-UCL
Positive regulation of endopeptidase activityManual Assertion Based On ExperimentIMP:UniProtKB
Protein processingManual Assertion Based On ExperimentIDA:HGNC-UCL
Golgi apparatus, Golgi stack membrane
Cell membrane
Membrane
Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
An autosomal dominant form of acne inversa, a chronic relapsing inflammatory disease of the hair follicles characterized by recurrent draining sinuses, painful skin abscesses, and disfiguring scars. Manifestations typically appear after puberty. Some ACNINV2 patients also exhibit reticulate hyperpigmentation consistent with Dowling-Degos disease.
Helical: 18-36
Cytoplasmic: 37-57
Helical: 58-78
Lumenal: 79-101
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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