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Mouse Anti-PSMA5 Recombinant Antibody (171-337) (CBMAB-0046-CN)

This product is a mouse antibody that recognizes PSMA5 of Dictyostelium discoideum. The antibody 171-337 can be used for immunoassay techniques such as: WB.
See all PSMA5 antibodies

Summary

Host Animal
Mouse
Specificity
D. discoideum, Dictyostelium
Clone
171-337
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Proteasome subunit 5
Specificity
D. discoideum, Dictyostelium
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Proteasome Subunit Alpha 5
Introduction
Subunit of the 20S proteasome (macropain), the endopeptidase complex involved in an ATP/ubiquitin-dependent nonlysosomal proteolytic pathway; in eukaryotes composed of up to 28 subunits, which form a highly ordered ring-shaped structure (20S ring). The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.
Entrez Gene ID
UniProt ID
Alternative Names
20S proteasome subunit alpha-5
Function
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.
Biological Process
Proteasomal protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Proteasome-mediated ubiquitin-dependent protein catabolic process1 PublicationIC:ComplexPortal
Cellular Location
Cytoplasm
Nucleus
Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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