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Mouse Anti-PSMB1 Recombinant Antibody (MCP421) (CBMAB-2113CQ)

This product is a mouse monoclonal antibody that recognizes PSMB1. The antibody MCP421 can be used for immunoassay techniques such as: WB, IHC-P.
See all PSMB1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
MCP421
Antibody Isotype
IgG
Application
WB, IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Proteasome subunit beta 1
Introduction
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene is tightly linked to the TBP (TATA-binding protein) gene in human and in mouse, and is transcribed in the opposite orientation in both species. Diseases associated with PSMB1 include Type 1 Diabetes Mellitus 8 and Cystic Fibrosis. Among its related pathways are RET signaling and CDK-mediated phosphorylation and removal of Cdc6.
Entrez Gene ID
5689
UniProt ID
P20618
Alternative Names
HC5; PSC5; PMSB1
Function
Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Biological Process
Proteasomal protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Proteasome-mediated ubiquitin-dependent protein catabolic process1 PublicationIC:ComplexPortal
Cellular Location
Cytoplasm
Nucleus
Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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