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Mouse Anti-PSMB5 Recombinant Antibody (HP903) (CBMAB-P3178-YC)

Provided herein is a Mouse monoclonal antibody against Human Proteasome Subunit Beta 5. The antibody can be used for immunoassay techniques, such as IHC, IP.
See all PSMB5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
HP903
Antibody Isotype
IgG
Application
IHC, IP

Basic Information

Immunogen
Human erythrocyte-derived proteasomes
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid in PBS containing 10 mM sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Proteasome Subunit Beta 5
Introduction
PSMB5 (Proteasome Subunit Beta 5) is a protein coding gene. Among its related pathways are Cell Cycle, Mitotic and RET signaling. Gene Ontology annotations related to this gene include peptidase activity and threonine-type endopeptidase activity. An important paralog of the gene is PSMB8.
Entrez Gene ID
5693
UniProt ID
P28074
Alternative Names
ZETA; PSC5; ZETA; PSC5
Function
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.
Biological Process
Proteasomal protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Proteasome-mediated ubiquitin-dependent protein catabolic process1 PublicationIC:ComplexPortal
ProteolysisManual Assertion Based On ExperimentIDA:MGI
Response to oxidative stressIEA:Ensembl
Cellular Location
Cytoplasm
Nucleus
Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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