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Mouse Anti-PSMB9 Recombinant Antibody (CBYJL-2328) (CBMAB-L2628-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Proteasome Subunit Beta 9 (PSMB9). The antibody can be used for immunoassay techniques, such as WB, FC, IHC, ICC, IF, IHC-P.
See all PSMB9 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Monkey
Clone
CBYJL-2328
Antibody Isotype
IgG2a
Application
WB, FC, IHC, ICC, IF, IHC-P

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 21-219 of human PSMB9(NP_002791) produced in E.coli.
Specificity
Human, Monkey
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 21-219

Target

Full Name
Proteasome subunit beta 9
Introduction
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMB9 is a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. PSMB9 is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit.
Entrez Gene ID
Human5698
Monkey716980
UniProt ID
HumanP28065
MonkeyF6UNF6
Alternative Names
LMP2; PRAAS3; PSMB6i; RING12; beta1i
Function
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues.
Biological Process
Immune system processIEA:UniProtKB-KW
Proteasomal protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cysteine-type endopeptidase activityManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Involvement in disease
Proteasome-associated autoinflammatory syndrome 3 (PRAAS3):
An autoinflammatory disorder characterized by onset in early infancy and recurrent fever, nodular dermatitis, myositis, panniculitis-induced lipodystrophy, lymphadenopathy, and immune dysregulation. Variable accompanying features may include joint contractures, hepatosplenomegaly, anemia, thrombocytopenia, recurrent infections, autoantibodies, and hypergammaglobulinemia. Some patients may have intracranial calcifications. PRAAS3 inheritance is autosomal recessive or digenic.
PTM
Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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