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Mouse Anti-PSMC2 Recombinant Antibody (CBYC-P706) (CBMAB-P3196-YC)

Provided herein is a Mouse monoclonal antibody against Human Proteasome 26S subunit, ATPase 2. The antibody can be used for immunoassay techniques, such as ELISA, ICC, WB.
See all PSMC2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-P706
Antibody Isotype
IgG1
Application
ELISA, ICC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2, 0.09% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-434

Target

Full Name
proteasome (prosome, macropain) 26S subunit, ATPase, 2
Introduction
PSMC2 (Proteasome 26S Subunit, ATPase 2) is a protein coding gene. Among its related pathways are Cell Cycle, Mitotic and RET signaling. Gene Ontology annotations related to this gene include hydrolase activity and ATPase activity.
Entrez Gene ID
5701
UniProt ID
P35998
Alternative Names
MSS1; Nbla10058; S7
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
Biological Process
Osteoblast differentiationManual Assertion Based On ExperimentHDA:UniProtKB
Positive regulation of proteasomal protein catabolic process1 PublicationIC:UniProtKB
Proteasome-mediated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Colocalizes with TRIM5 in cytoplasmic bodies.
PTM
Monoubiquitinated by RNF181.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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