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Mouse Anti-PSMC3 Recombinant Antibody (CBT2123) (V2LY-0625-LY565)


See all PSMC3 antibodies
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Tested Data
Mouse Anti-PSMC3 Recombinant Antibody (CBT2123) (V2LY-0625-LY565) in ELISA
Mouse Anti-PSMC3 Recombinant Antibody (CBT2123) (V2LY-0625-LY565) in ELISA
Mouse Anti-PSMC3 Recombinant Antibody (CBT2123) (V2LY-0625-LY565) in WB
Mouse Anti-PSMC3 Recombinant Antibody (CBT2123) (V2LY-0625-LY565) in WB
Mouse Anti-PSMC3 Recombinant Antibody (CBT2123) (V2LY-0625-LY565) in WB
Mouse Anti-PSMC3 Recombinant Antibody (CBT2123) (V2LY-0625-LY565) in WB
Mouse Anti-PSMC3 Recombinant Antibody (CBT2123) (V2LY-0625-LY565) in WB
Mouse Anti-PSMC3 Recombinant Antibody (CBT2123) (V2LY-0625-LY565) in WB
Mouse Anti-PSMC3 Recombinant Antibody (CBT2123) (V2LY-0625-LY565) in IF
Mouse Anti-PSMC3 Recombinant Antibody (CBT2123) (V2LY-0625-LY565) in IF
Mouse Anti-PSMC3 Recombinant Antibody (CBT2123) (V2LY-0625-LY565) in FC
Mouse Anti-PSMC3 Recombinant Antibody (CBT2123) (V2LY-0625-LY565) in FC
Mouse Anti-PSMC3 Recombinant Antibody (CBT2123) (V2LY-0625-LY565) in IHC
Mouse Anti-PSMC3 Recombinant Antibody (CBT2123) (V2LY-0625-LY565) in IHC
Mouse Anti-PSMC3 Recombinant Antibody (CBT2123) (V2LY-0625-LY565) in IHC
Mouse Anti-PSMC3 Recombinant Antibody (CBT2123) (V2LY-0625-LY565) in IHC

Summary

Host Animal
Mouse
Specificity
Human, Monkey, Rat
Clone
CBT2123
Antibody Isotype
IgG1
Application
WB, IHC, ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human PSMC3 (AA: 53-152) expressed in E. Coli.
Host Species
Mouse
Specificity
Human, Monkey, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ICC1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
5702
UniProt ID
P17980
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
Biological Process
Modulation by host of viral transcriptionManual Assertion Based On ExperimentIDA:GO_Central
Positive regulation of proteasomal protein catabolic process1 PublicationIC:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:GO_Central
Proteasome-mediated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Nucleus
Colocalizes with TRIM5 in the cytoplasmic bodies.
Involvement in disease
Deafness, cataract, impaired intellectual development, and polyneuropathy (DCIDP):
An autosomal recessive disease characterized by early onset of deafness, cataract, severe developmental delay, and severely impaired intellectual development. Patients later develop polyneuropathy of the lower extremities, associated with depigmentation of the hair in that area.
PTM
Sumoylated by UBE2I in response to MEKK1-mediated stimuli.
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For research use only. Not intended for any clinical use.

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