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Mouse Anti-PSMD4 Recombinant Antibody (AH1.1) (CBMAB-P3228-YC)

Provided herein is a Mouse monoclonal antibody against Human Proteasome 26S Subunit, Non-ATPase 4. The antibody can be used for immunoassay techniques, such as WB.
See all PSMD4 antibodies
Published Data
Fig.1 Immunoblots show interaction between endogenous BBS4 and GFP-tagged RPN10.
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Fig.2 Nuclear enrichment and foci colocalization of immunofluorescently labeled mammalian proteasomal subunit Psmd4 (RP).
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Summary

Host Animal
Mouse
Specificity
Human, Frog
Clone
AH1.1
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Sub-unit 5a
Specificity
Human, Frog
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PSMD4
Introduction
PSMD4 (Proteasome 26S Subunit, Non-ATPase 4) is a protein coding gene. Diseases associated with PSMD4 include Angelman Syndrome. Among its related pathways are Cell Cycle, Mitotic and RET signaling. Gene Ontology annotations related to this gene include identical protein binding.
Entrez Gene ID
Human5710
Frog407871
UniProt ID
HumanP55036
FrogQ6NVQ2
Alternative Names
MIP224; RPT3; TBP-7; S6; MIP224; RPT3; S6; TBP-7; TBP7; TBP7
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains.
Biological Process
Proteasome-mediated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
cytosol
nucleoplasm
nucleus
proteasome accessory complex
proteasome complex
proteasome regulatory particle, base subcomplex
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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