Sign in or Register   Sign in or Register
  |  

Mouse Anti-PTGER3 Recombinant Antibody (5F5) (CBMAB-P3324-YC)

Provided herein is a Mouse monoclonal antibody against Human Prostaglandin E Receptor 3. The antibody can be used for immunoassay techniques, such as WB.
See all PTGER3 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat, Cattle
Clone
5F5
Antibody Isotype
IgG2a
Application
WB

Basic Information

Specificity
Human, Rat, Cattle
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Prostaglandin E Receptor 3
Introduction
PTGER3 is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli.
Entrez Gene ID
Human5733
Cattle282330
Rat24929
UniProt ID
HumanP43115
CattleP34979
RatP34980
Alternative Names
EP3R; EP3-IV; PGE2-R; EP3-VI; Ptgerep3; EP3e; Rep3; EP3; Pgerep3; EP3-I; EP3-III; EP3-II; PTGEREP3; rEP3a; rEP3b
Function
Receptor for prostaglandin E2 (PGE2) (PubMed:8307176, PubMed:7883006, PubMed:8117308, PubMed:8135729, PubMed:7981210).
The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G(i) proteins, and to an elevation of intracellular calcium (PubMed:7883006, PubMed:8117308, PubMed:8135729, PubMed:7981210).
Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3- secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality (By similarity).
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cell deathManual Assertion Based On ExperimentTAS:ProtInc
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Intestine smooth muscle contractionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of gastric acid secretionManual Assertion Based On ExperimentIBA:GO_Central
Phospholipase C-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cytosolic calcium ion concentrationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of fever generationISS:BHF-UCL
Cellular Location
Cell membrane
Topology
Extracellular: 1-53
Helical: 54-78
Cytoplasmic: 79-91
Helical: 92-112
Extracellular: 113-131
Helical: 132-153
Cytoplasmic: 154-175
Helical: 176-197
Extracellular: 198-227
Helical: 228-253
Cytoplasmic: 254-283
Helical: 284-307
Extracellular: 308-327
Helical: 328-349
Cytoplasmic: 350-390
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-PTGER3 Recombinant Antibody (5F5)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare