Mouse Anti-PTPN1 Recombinant Antibody (CBT4081) (V2LY-0625-LY204)

PTPN1

Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.

Actin cytoskeleton reorganizationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to unfolded proteinManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Endoplasmic reticulum unfolded protein responseManual Assertion Based On ExperimentIDA:UniProtKB
Growth hormone receptor signaling pathway via JAK-STATTAS:Reactome
Insulin receptor signaling pathwayIEA:Ensembl
IRE1-mediated unfolded protein responseISS:ARUK-UCL
Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayISS:ARUK-UCL
Negative regulation of ERK1 and ERK2 cascadeISS:BHF-UCL
Negative regulation of insulin receptor signaling pathway1 PublicationNAS:BHF-UCL
Negative regulation of MAP kinase activityManual Assertion Based On ExperimentIMP:CACAO
Negative regulation of PERK-mediated unfolded protein responseManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Negative regulation of signal transductionTAS:Reactome
Negative regulation of vascular endothelial growth factor receptor signaling pathwayISS:BHF-UCL
Peptidyl-tyrosine dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activityISS:BHF-UCL
Platelet-derived growth factor receptor-beta signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of IRE1-mediated unfolded protein responseManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Positive regulation of JUN kinase activityISS:ARUK-UCL
Positive regulation of protein tyrosine kinase activityManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Positive regulation of receptor catabolic processManual Assertion Based On ExperimentIMP:CACAO
Protein dephosphorylationManual Assertion Based On ExperimentIMP:CACAO
Regulation of endocytosisManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of hepatocyte growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of intracellular protein transportManual Assertion Based On ExperimentIMP:CACAO
Regulation of signal transductionManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of type I interferon-mediated signaling pathwayTAS:Reactome

Endoplasmic reticulum membrane
Interacts with EPHA3 at the cell membrane.

Oxidized on Cys-215; the Cys-SOH formed in response to redox signaling reacts with the alpha-amido of the following residue to form a sulfenamide cross-link, triggering a conformational change that inhibits substrate binding and activity. The active site can be restored by reduction.
Ser-50 is the major site of phosphorylation as compared to Ser-242 and Ser-243. Activated by phosphorylation at Ser-50.
S-nitrosylation of Cys-215 inactivates the enzyme activity.
Sulfhydration at Cys-215 following endoplasmic reticulum stress inactivates the enzyme activity, promoting EIF2AK3/PERK activity.