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Rabbit Anti-PTPN18 Recombinant Antibody (D7B9) (CBMAB-P3431-YC)

Provided herein is a Rabbit monoclonal antibody against Human Protein tyrosine phosphatase, non-receptor type 18. The antibody can be used for immunoassay techniques, such as WB, IP.
See all PTPN18 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
D7B9
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Protein tyrosine phosphatase, non-receptor type 18
Introduction
PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases.
Entrez Gene ID
26469
UniProt ID
Q99952
Alternative Names
BDP1; PTP-HSCF
Function
Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.
Biological Process
Blastocyst formationIEA:Ensembl
Negative regulation of ERBB signaling pathwayTAS:Reactome
Peptidyl-tyrosine dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Protein dephosphorylationManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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