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Mouse Anti-PTPRN Recombinant Antibody (A1410) (CBMAB-AP10802LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
A1410
Antibody Isotype
IgG3
Application
ELISA, IF, IHC, WB

Basic Information

Immunogen
Fusion protein of IA-2/PTPRN
Specificity
Human
Antibody Isotype
IgG3
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
5798
UniProt ID
Q16849
Alternative Names
FLJ16131,IA 2/PTP,IA2,IA-2,ICA 512,ICA3,ICA512,Islet cell antigen 512,Islet cell autoantigen 3,PTP IA 2,PTPRN,R PTP N
Function
E-AB-27194
Biological Process
Dense core granule maturationManual Assertion Based On ExperimentIGI:GO_Central
Insulin secretionManual Assertion Based On ExperimentIGI:GO_Central
Insulin secretion involved in cellular response to glucose stimulusISS:UniProtKB
LuteinizationISS:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of type B pancreatic cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of secretionManual Assertion Based On ExperimentIBA:GO_Central
Response to reactive oxygen speciesManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Membrane
Cytoplasmic vesicle, secretory vesicle membrane
Perikaryon
Cell projection, axon
Synapse
Cell membrane
Endosome
Detected on neuronal secretory vesicles, but not on synaptic vesicles. Colocalizes with insulin-containing secretory granules (PubMed:25561468).
Primarily detected on secretory vesicle membranes. Transiently found at the cell membrane, when secretory vesicles fuse with the cell membrane to release their cargo. Is then endocytosed and recycled to secretory vesicles via the Golgi apparatus membranes.
ICA512-transmembrane fragment
Cytoplasmic vesicle, secretory vesicle membrane
ICA512-cleaved cytosolic fragment
Nucleus
Involvement in disease
Autoantigen in insulin-dependent diabetes mellitus (IDDM).
Topology
Lumenal: 35-575
Helical: 576-600
Cytoplasmic: 601-979
PTM
N-glycosylated.
O-glycosylated with core 1 or possibly core 8 glycans.
Subject to proteolytic cleavage at multiple sites (PubMed:11483505).
Subject to cleavage on a pair of basic residues (By similarity).
On exocytosis of secretory granules in pancreatic beta-cells ICA512-TMF is transiently inserted in the plasma-membrane and cleaved by mu-type calpain CPN1 to yield ICA512-CCF (By similarity).
Sumoylated at two sites including Lys-754. Sumoylation decreases interaction with STAT5.
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For research use only. Not intended for any clinical use.

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