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Mouse Anti-PUS7 Recombinant Antibody (4C6) (CBMAB-P3533-YC)

Provided herein is a Mouse monoclonal antibody against Human Pseudouridylate synthase 7 (putative). The antibody can be used for immunoassay techniques, such as WB, IF, FC.
See all PUS7 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Dog, Rat, Monkey
Clone
4C6
Antibody Isotype
IgG1
Application
WB, IF, FC

Basic Information

Specificity
Human, Dog, Rat, Monkey
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Pseudouridylate synthase 7 (putative)
Introduction
PUS7 has ubiquitous expression in thyroid (RPKM 5.5), skin (RPKM 3.6) and 25 other tissues.
Entrez Gene ID
Human54517
Rat296751
Monkey697463
Dog100856353
UniProt ID
HumanQ96PZ0
RatD4ADZ9
MonkeyA0A1D5R820
DogE2RAX2
Alternative Names
pseudouridylate synthase 7 (putative)
Function
Pseudouridylate synthase that catalyzes pseudouridylation of RNAs (PubMed:28073919, PubMed:29628141, PubMed:30778726, PubMed:31477916, PubMed:35051350, PubMed:34718722).
Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex (PubMed:29628141).
Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3' (PubMed:28073919, PubMed:31477916, PubMed:35051350).
Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions (PubMed:35051350).
Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing (PubMed:35051350).
In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types (PubMed:29628141).
Biological Process
mRNA processingIEA:UniProtKB-KW
mRNA pseudouridine synthesisManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of translationManual Assertion Based On ExperimentIDA:UniProtKB
Pseudouridine synthesisManual Assertion Based On ExperimentIBA:GO_Central
Regulation of hematopoietic stem cell differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of mesoderm developmentManual Assertion Based On ExperimentIMP:UniProtKB
RNA splicingIEA:UniProtKB-KW
tRNA pseudouridine synthesisManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
Involvement in disease
Intellectual developmental disorder with abnormal behavior, microcephaly, and short stature (IDDABS):
An autosomal recessive disorder characterized by intellectual disability, developmental delay with poor or absent speech, short stature, progressive microcephaly, hyperactivity and aggressive behavior. Some patients manifest sensorineural hearing loss.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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