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Mouse Anti-PWWP2B Monoclonal Antibody (1C8) (CBMAB-0021-LY)

This product is mouse monoclonal antibody recognizes PWWP2B of human. The antibody 1C8 immunoassay techniques such as: ELISA, WB, IP.
See all PWWP2B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1C8
Antibody Isotype
IgG2b
Application
ELISA, WB. IP

Basic Information

Immunogen
Recombinant peptide (Full Length)
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
PWWP2B
Introduction
This gene encodes a protein that is composed of ~90 residues and is present within all eukaryotes. PWWP domains have been found in more than 60 proteins which are involved in the processes of transcriptional regulation, DNA methylation, and DNA repair.
Entrez Gene ID
UniProt ID
Function
Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260).
Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260).
Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (By similarity).
Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (By similarity).
Biological Process
Negative regulation of histone acetylationISS:UniProtKB
Negative regulation of histone H3-K27 acetylationISS:UniProtKB
Negative regulation of histone H3-K9 acetylationISS:UniProtKB
Positive regulation of transcription elongation from RNA polymerase II promoterISS:UniProtKB
Regulation of cold-induced thermogenesisISS:UniProtKB
Cellular Location
nucleoplasm
nucleus
PTM
Deubiquitinated by BRCC3; leading to its stabilization.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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