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Mouse Anti-PYDC1 Recombinant Antibody (5D12) (CBMAB-P3571-YC)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
5D12
Application
WB
Immunogen
Full length human recombinant protein of human PYDC1 (NP_690865) produced in E. coli
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Pyrin domain containing 1
Introduction
Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.
Entrez Gene ID
260434
UniProt ID
Q8WXC3
Alternative Names
cPOP1; POP1; PYC1; ASC2
Function
Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.
Biological Process
Biological Process innate immune responseManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process negative regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process negative regulation of protein kinase activityManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process negative regulation of tumor necrosis factor-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process proteolysisIEA:InterPro
Biological Process tumor necrosis factor-mediated signaling pathwayManual Assertion Based On ExperimentIDA:HGNC-UCL
Cellular Location
Cytoplasm
Recruited to specks formed by PYCARD within the cytoplasm.
PTM
Phosphorylated.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-PYDC1 Recombinant Antibody (9C10) (CAT#: CBMAB-P3572-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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