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Mouse Anti-PYGL Recombinant Antibody (CBLG1-2428) (CBMAB-G6517-LY)

This product is antibody recognizes PYGL. The antibody CBLG1-2428 immunoassay techniques such as: WB.
See all PYGL antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-2428
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Glycogen Phosphorylase, Liver
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% NaN3
Concentration
0.5 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
liver glycogen phosphorylase
Introduction
This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.
Entrez Gene ID
UniProt ID
Alternative Names
GSD6
Function
Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
Biological Process
Biological Process 5-phosphoribose 1-diphosphate biosynthetic processIEA:Ensembl
Biological Process glucose homeostasisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process glycogen catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process glycogen metabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process necroptotic processIEA:Ensembl
Biological Process response to bacteriumIEA:Ensembl
Cellular Location
Cytoplasm, cytosol
Involvement in disease
Glycogen storage disease 6 (GSD6):
A metabolic disorder characterized by mild to moderate hypoglycemia, mild ketosis, growth retardation, and prominent hepatomegaly. Heart and skeletal muscle are not affected.
PTM
Acetylation, which is up-regulated by glucose and insulin and down-regulated by glucagon, inhibits the glycogen phosphorylase activity by promoting PPP1R3B-mediated recruitment of phosphatase PP1 and Ser-15 dephosphorylation.
Phosphorylation at Ser-15 converts inactive phosphorylase b into active phosphorylase a (PubMed:10949035).
Dephosphorylation of Ser-15 by phosphatase PP1 inactivates the enzyme (PubMed:22225877).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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