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Mouse Anti-PZP Recombinant Antibody (CBYC-P813) (CBMAB-P3587-YC)

Provided herein is a Mouse monoclonal antibody against Human PZP, Alpha-2-Macroglobulin Like. The antibody can be used for immunoassay techniques, such as WB.
See all PZP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-P813
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Human embryonic kidney cell line HEK293-derived Recombinant human Pregnancy Zone Protein/PZP, Thr26-Val1482
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized from PBS with trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PZP, Alpha-2-Macroglobulin Like
Introduction
PZP is highly expressed in late-pregnancy serum and is similar in structure to alpha-2-macroglobulin. The encoded protein, which acts as a homotetramer, inhibits the activity of all four classes of proteinases. This protein contains cleavage sites for several proteinases. Upon binding of a proteinase, the conformation of this protein changes to trap the proteinase, limiting its activity.
Entrez Gene ID
5858
UniProt ID
P20742
Alternative Names
CPAMD6
Function
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Biological Process
Female pregnancy
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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