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Mouse Anti-RAB23 Recombinant Antibody (427CT2.1.1) (CBMAB-R0006-CN)

This product is a Mouse antibody that recognizes RAB23. The antibody 427CT2.1.1 can be used for immunoassay techniques such as: ELISA, WB.
See all RAB23 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
427CT2.1.1
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Immunogen
Purified His-tagged RAB23 protein (fragment)
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
0.09% Sodium azide

Target

Full Name
RAB23, Member RAS Oncogene Family
Introduction
This gene encodes a small GTPase of the Ras superfamily. Rab proteins are involved in the regulation of diverse cellular functions associated with intracellular membrane trafficking, including autophagy and immune response to bacterial infection. The encoded protein may play a role in central nervous system development by antagonizing sonic hedgehog signaling. Disruption of this gene has been implicated in Carpenter syndrome as well as cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Entrez Gene ID
Human51715
Mouse19335
UniProt ID
HumanQ9ULC3
MouseP35288
Alternative Names
RAB23, Member RAS Oncogene Family; RAB Family Small GTP Binding Protein RAB 23; Ras-Related Protein Rab-23; HSPC137;
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes.
Biological Process
Biological Process autophagosome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular defense responseManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cilium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process craniofacial suture morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process GTP metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of protein import into nucleusManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane
Cytoplasm
Cytoplasmic vesicle, autophagosome
Endosome membrane
Cytoplasmic vesicle, phagosome
Cytoplasmic vesicle, phagosome membrane
Recruited to phagosomes containing S.aureus or M.tuberculosis.
Involvement in disease
Carpenter syndrome 1 (CRPT1):
A rare autosomal recessive disorder characterized by acrocephaly with variable synostosis of the sagittal, lambdoid, and coronal sutures; peculiar facies; brachydactyly of the hands with syndactyly; preaxial polydactyly and syndactyly of the feet; congenital heart defects; growth retardation; intellectual disability; hypogenitalism; and obesity. In addition, cerebral malformations, oral and dental abnormalities, coxa valga, genu valgum, hydronephrosis, precocious puberty, and hearing loss may be observed.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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