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Mouse Anti-RABEP1 Recombinant Antibody (20/Rabaptin-5) (CBMAB-R0961-CN)

This product is a Mouse antibody that recognizes RABEP1. The antibody 20/Rabaptin-5 can be used for immunoassay techniques such as: WB, IF.
See all RABEP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
20/Rabaptin-5
Antibody Isotype
IgG1
Application
WB, IF

Basic Information

Immunogen
Human Rabaptin-5 aa. 247-417
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.25 mg/mL

Target

Full Name
rabaptin, RAB GTPase binding effector protein 1
Introduction
RABEP1 (Rabaptin, RAB GTPase Binding Effector Protein 1) is a Protein Coding gene. Diseases associated with RABEP1 include Tuberous Sclerosis 2. Among its related pathways are Delta508-CFTR traffic / Sorting endosome formation in CF and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and growth factor activity. An important paralog of this gene is RABEP2.
Entrez Gene ID
Human9135
Mouse54189
Rat54190
UniProt ID
HumanQ15276
MouseO35551
RatO35550
Alternative Names
Rabaptin, RAB GTPase Binding Effector Protein 1; Renal Carcinoma Antigen NY-REN-17; Rabaptin-5alpha; Rabaptin-4; Rabaptin-5; RAB5EP;
Function
Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed:22841712).
Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium (By similarity).
Biological Process
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process endocytosisManual Assertion Based On ExperimentTAS:ProtInc
Biological Process Golgi to plasma membrane transportISS:UniProtKB
Biological Process membrane fusionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process protein localization to ciliary membraneISS:UniProtKB
Biological Process protein transportIEA:UniProtKB-KW
Biological Process vesicle-mediated transportManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Early endosome
Recycling endosome
Cytoplasmic vesicle
PTM
Proteolytic cleavage by caspases in apoptotic cells causes loss of endosome fusion activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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