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Mouse Anti-RABL2B Recombinant Antibody (1B10) (CBMAB-R0983-CN)

This product is a Mouse antibody that recognizes RABL2B. The antibody 1B10 can be used for immunoassay techniques such as: ELISA, WB.
See all RABL2B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1B10
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa. 1-230 from RABL2B (H14879) with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
RAB, member of RAS oncogene family-like 2B
Introduction
The RABL2B protein is a member of the RAB gene family which belongs to the RAS GTPase superfamily. RABL2B is located within a subtelomeric region of 22q13.3. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Entrez Gene ID
11158
UniProt ID
Q9UNT1
Alternative Names
RAB, Member Of RAS Oncogene Family Like 2B;
Function
Small GTPase required for ciliation. Activated in a guanine nucleotide exchange factor (GEF)-independent manner via its intrinsic GDP for GTP nucleotide exchange ability (PubMed:28625565).
Involved in ciliary assembly by binding the intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia (PubMed:28625565, PubMed:28428259).
Biological Process
Biological Process cilium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process intraciliary transportManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
Cytoplasm, cytoskeleton, cilium basal body
Cytoplasm
Localizes on the mother centriole. Localizes slightly apical to the subdistal appendage, but below the distal appendage.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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