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Mouse Anti-RAD9A Recombinant Antibody (M80573) (CBMAB-R1153-CN)

This product is a Mouse antibody that recognizes RAD9A. The antibody M80573 can be used for immunoassay techniques such as: WB, IP.
See all RAD9A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
M80573
Antibody Isotype
IgG1
Application
WB, IP

Basic Information

Immunogen
A purified recombinant human Rad9A protein fragments expressed in E. coli
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL

Target

Full Name
RAD9 Checkpoint Clamp Component A
Introduction
This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Entrez Gene ID
5883
UniProt ID
Q99638
Alternative Names
RAD9 Checkpoint Clamp Component A; DNA Repair Exonuclease Rad9 Homolog A; HRAD9; Cell Cycle Checkpoint Control Protein RAD9A; RAD9 Homolog A (S. Pombe); RAD9 (S. Pombe) Homolog; RAD9 Homolog A; EC 3.1.11.2; RAD9;
Function
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex.
Biological Process
Biological Process cellular response to DNA damage stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to ionizing radiationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process DNA damage checkpoint signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process DNA repairManual Assertion Based On ExperimentIBA:GO_Central
Biological Process DNA replication checkpoint signalingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process intrinsic apoptotic signaling pathway in response to DNA damageIEA:Ensembl
Biological Process mitotic intra-S DNA damage checkpoint signalingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of intrinsic apoptotic signaling pathway in response to DNA damageIEA:Ensembl
Cellular Location
Nucleus
PTM
Constitutively phosphorylated on serine and threonine amino acids in absence of DNA damage. Hyperphosphorylated by PRKCD and ABL1 upon DNA damage. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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