Rabbit Anti-RALBP1 Recombinant Antibody (D87H8) (CBMAB-R1247-CN)
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Basic Information
Target
| Human | Q15311 |
| Monkey | A0A5F7ZZV2 |
As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7673236).
As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis (PubMed:10910768, PubMed:12775724).
During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle (PubMed:12775724).
During mitosis, also controls mitochondrial fission as an effector of RALA (PubMed:21822277).
Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (PubMed:21822277).
Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance.
Biological Process doxorubicin transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of mitochondrial fissionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of Cdc42 protein signal transductionISS:UniProtKB
Biological Process regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of small GTPase mediated signal transductionTAS:Reactome
Biological Process small GTPase mediated signal transductionManual Assertion Based On ExperimentIPI:UniProtKB
Biological Process transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process xenobiotic detoxification by transmembrane export across the plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Cytoplasm, cytosol
Cytoplasm, cytoskeleton, spindle pole
Nucleus
Mitochondrion
Cytosolic protein that transiently associates with the mitotic spindle poles in early prophase, and dissociates from them after completion of mitosis (By similarity).
Targeted to the plasma membrane through its interaction with RALB, directed by FGF signaling. Docking on the membrane is required to transduce the Ral signal (By similarity).
Recruited by RALA to the mitochondrion during mitosis where it regulates mitochondrial fission (PubMed:21822277).
Nuclear localization is cell cycle dependent while membrane localization is seen in adherent cells (PubMed:22319010).
The region involved in membrane association could form transmembrane domains and expose a part of the protein extracellularly (Probable)
May undergo proteolytic cleavage to give peptides which reassemble to form a transporter complex.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Antibody Pairs
RALBP1 Matched Antibody Pair (966) (CAT#: APMAB-966LY)
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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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