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Rabbit Anti-RANBP3 Recombinant Antibody (B24H15L41) (CBMAB-R1276-CN)

This product is a Rabbit antibody that recognizes RANBP3. The antibody B24H15L41 can be used for immunoassay techniques such as: FC, ICC, IF, WB.
See all RANBP3 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
B24H15L41
Antibody Isotype
IgG
Application
FC, ICC, IF, WB

Basic Information

Immunogen
A recombinant protein corresponding to aa. 151-228
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS
Preservative
0.09% Sodium azide
Concentration
0.5 mg/mL

Target

Full Name
RAN binding protein 3
Introduction
This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Entrez Gene ID
8498
UniProt ID
Q9H6Z4
Alternative Names
RAN Binding Protein 3; RanBP3;
Function
Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.
Biological Process
Biological Process protein export from nucleusManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of catalytic activityIEA:GOC
Cellular Location
Cytoplasm
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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