Rabbit Anti-RAPH1 Recombinant Antibody (CBYJL-065) (CBMAB-L0117-YJ)

Name: Rabbit Anti-RAPH1 Recombinant Antibody (CBYJL-065)
SKU: CBMAB-L0117-YJ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Rabbit

Clone

CBYJL-065

Application

WB, IF

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Ras Association (RalGDS/AF-6) And Pleckstrin Homology Domains 1

Introduction

Gene of RAPH1 encodes a protein that belongs to the Mig10/Rap1-interacting adaptor molecule/Lamellipodin family of adapter proteins, which play a role in cell migration. Members of this family contain Ras-association domains, pleckstrin-homology domains, and proline-rich C-termini. RAPH1 regulates actin dynamics through interaction with Ena/Vasodilator proteins as well as direct binding to filamentous actin to regulate actin network assembly. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

65059

UniProt ID

Q70E73

Alternative Names

Ras Association (RalGDS/AF-6) And Pleckstrin Homology Domains 1; Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region; Candidate 18; Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region; Candidate 9; Proline-Rich EVH1 Ligand 2; Lamellipodin; ALS2CR18; ALS2CR9; PREL-2; PREL2

Function

Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion.

Biological Process

Biological Process axon extensionIEA:Ensembl
Biological Process signal transductionIEA:InterPro

Cellular Location

Cell membrane
Cell projection, lamellipodium
Cell projection, filopodium
Cytoplasm, cytoskeleton
Recruited to the membrane, via the PH domain, by the phosphoinositide, PI(3,4)P2. Colocalizes with ENAH/VASP at the tips of lamellipodia and filopodia. Also colocalizes with the pathogens, Vaccinia and Enteropathogenic E.coli (EPEC) at the interface between the pathogen and their actin.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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