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Rabbit Anti-RAPH1 Recombinant Antibody (CBYJL-065) (CBMAB-L0117-YJ)

Provided herein is a Rabbit monoclonal antibody, which binds to Ras Association (RalGDS/AF-6) And Pleckstrin Homology Domains 1 (RAPH1). The antibody can be used for immunoassay techniques, such as WB, IF.
See all RAPH1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBYJL-065
Antibody Isotype
IgG
Application
WB, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ras Association (RalGDS/AF-6) And Pleckstrin Homology Domains 1
Introduction
Gene of RAPH1 encodes a protein that belongs to the Mig10/Rap1-interacting adaptor molecule/Lamellipodin family of adapter proteins, which play a role in cell migration. Members of this family contain Ras-association domains, pleckstrin-homology domains, and proline-rich C-termini. RAPH1 regulates actin dynamics through interaction with Ena/Vasodilator proteins as well as direct binding to filamentous actin to regulate actin network assembly. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
65059
UniProt ID
Q70E73
Alternative Names
Ras Association (RalGDS/AF-6) And Pleckstrin Homology Domains 1; Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region; Candidate 18; Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region; Candidate 9; Proline-Rich EVH1 Ligand 2; Lamellipodin; ALS2CR18; ALS2CR9; PREL-2; PREL2
Function
Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion.
Biological Process
Biological Process axon extensionIEA:Ensembl
Biological Process signal transductionIEA:InterPro
Cellular Location
Cell membrane
Cell projection, lamellipodium
Cell projection, filopodium
Cytoplasm, cytoskeleton
Recruited to the membrane, via the PH domain, by the phosphoinositide, PI(3,4)P2. Colocalizes with ENAH/VASP at the tips of lamellipodia and filopodia. Also colocalizes with the pathogens, Vaccinia and Enteropathogenic E.coli (EPEC) at the interface between the pathogen and their actin.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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