Mouse Anti-RARRES2 Antibody (1G2) (CBMAB-0061-YC)

Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a pro-inflammatory adipokine, causing an increase in secretion of pro-inflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Its dual role in inflammation and metabolism might provide a link between chronic inflammation and obesity, as well as obesity-related disorders such as type 2 diabetes and cardiovascular disease. Exhibits an antimicrobial function in the skin.
Biological Process antifungal innate immune responseManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process chemotaxisIEA:UniProtKB-KW
Biological Process defense response to Gram-negative bacteriumManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process embryonic digestive tract developmentManual Assertion Based On ExperimentIMP:DFLAT
Biological Process inflammatory responseIEA:UniProtKB-KW
Biological Process innate immune responseManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process insulin receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of chemotaxisISS:UniProtKB
Biological Process positive regulation of fat cell differentiationISS:UniProtKB
Biological Process positive regulation of macrophage chemotaxisManual Assertion Based On ExperimentIMP:DFLAT
Biological Process positive regulation of protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of lipid catabolic processISS:UniProtKB
Biological Process retinoid metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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