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Mouse Anti-RBM5 Recombinant Antibody (CBYJL-241) (CBMAB-L0339-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to RNA Binding Motif Protein 5 (RBM5). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all RBM5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-241
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
RNA binding motif protein 5
Introduction
Gene of RBM5 is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. RBM5 plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. Gene of RBM5 is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer.
Entrez Gene ID
10181
UniProt ID
P52756
Alternative Names
RNA Binding Motif Protein 5; Putative Tumor Suppressor LUCA15; Renal Carcinoma Antigen NY-REN-9; RNA-Binding Motif Protein 5; RNA-Binding Protein 5; Protein G15
Function
Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.
Biological Process
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of alternative mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process RNA processingManual Assertion Based On ExperimentTAS:ProtInc
Biological Process spliceosomal complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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