Mouse Anti-RCBTB1 Recombinant Antibody (1E4) (CBMAB-R1919-CN)

Name: Mouse Anti-RCBTB1 Recombinant Antibody (1E4)
SKU: CBMAB-R1919-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1E4

Application

ELISA, WB

Immunogen

Partial recombinant corresponding to aa. 2-91 from human RCBTB1 (NP_060661) with GST tag

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

More Infomation

Target

Full Name

regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1

Introduction

This gene encodes a protein with an N-terminal RCC1 domain and a C-terminal BTB (broad complex, tramtrack and bric-a-brac) domain. In rat, over-expression of this gene in vascular smooth muscle cells induced cellular hypertrophy. In rat, the C-terminus of RCBTB1 interacts with the angiotensin II receptor-1A. In humans, this gene maps to a region of chromosome 13q that is frequently deleted in B-cell chronic lymphocytic leukemia and other lymphoid malignancies. [provided by RefSeq, Jul 2008]

Entrez Gene ID

55213

UniProt ID

Q8NDN9

Alternative Names

RCC1 And BTB Domain Containing Protein 1; Regulator Of Chromosome Condensation (RCC1) And BTB (POZ) Domain Containing Protein 1; Regulator Of Chromosome Condensation And BTB Domain-Containing Protein 1; Chronic Lymphocytic Leukemia Deletion Region Gene 7 Protein; CLL Deletion Region Gene 7 Protein; CLLD7; GDP/GTP Exchange Factor (GEF)-Like Protein;

Function

May be involved in cell cycle regulation by chromatin remodeling.

Biological Process

Biological Process cell cycleIEA:UniProtKB-KW
Biological Process chromatin organizationIEA:UniProtKB-KW

Cellular Location

Nucleus

Involvement in disease

Retinal dystrophy with or without extraocular anomalies (RDEOA):
An autosomal recessive disease characterized by progressive retinal dystrophy, chorioretinal macular atrophy, reduced cone and rod responses on ERG, and decrease visual acuity. Extraocular anomalies are variably present in some patients and include pulmonary fibrosis, sensorineural hearing loss, and endocrine features such as goiter and primary ovarian insufficiency.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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