Mouse Anti-RECQL4 Recombinant Antibody (2G8) (CBMAB-R2018-CN)

Name: Mouse Anti-RECQL4 Recombinant Antibody (2G8)
SKU: CBMAB-R2018-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

2G8

Application

ELISA, IHC

Immunogen

Full-length recombinant protein corresponding to aa. 1-652 from human RECQL4 (H13277) with GST tag

Specificity

Human, Mouse

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

More Infomation

Target

Full Name

RecQ protein-like 4

Introduction

The protein encoded by this gene is a DNA helicase that belongs to the RecQ helicase family. DNA helicases unwind double-stranded DNA into single-stranded DNAs and may modulate chromosome segregation. This gene is predominantly expressed in thymus and testis. Mutations in this gene are associated with Rothmund-Thomson, RAPADILINO and Baller-Gerold syndromes. [provided by RefSeq, Jan 2010]

Entrez Gene ID

Human	9401
Mouse	79456

UniProt ID

Human	O94761
Mouse	Q75NR7

Alternative Names

RecQ Like Helicase 4; RecQ Helicase-Like 4; RecQ Protein-Like 4; RECQ4; DNA Helicase, RecQ-Like, Type 4; DNA Helicase, RecQ-Like Type 4; ATP-Dependent DNA Helicase Q4; EC 3.6.4.12; RTS;

Function

DNA-dependent ATPase. May modulate chromosome segregation.

Biological Process

Biological Process DNA duplex unwindingManual Assertion Based On ExperimentIDA:GO_Central
Biological Process DNA recombinationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process DNA repairManual Assertion Based On ExperimentIBA:GO_Central
Biological Process DNA replicationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process DNA unwinding involved in DNA replicationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process telomere maintenanceManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process telomeric D-loop disassemblyManual Assertion Based On ExperimentIDA:BHF-UCL

Cellular Location

Cytoplasm
Nucleus

Involvement in disease

RAPADILINO syndrome (RAPADILINOS):
Disease characterized by radial and patellar aplasia or hypoplasia.
Baller-Gerold syndrome (BGS):
An autosomal recessive syndrome characterized by short stature, craniosynostosis, absent or hypoplastic radii, short and curved ulna, fused carpal bones and absent carpals, metacarpals and phalanges. Some patients manifest poikiloderma. Cases reported as Baller-Gerold syndrome have phenotypic overlap with several other disorders, including Saethre-Chotzen syndrome.
Rothmund-Thomson syndrome 2 (RTS2):
An autosomal recessive disorder characterized by dermatological features such as skin atrophy, pigmentation abnormalities, and telangiectasia. It is frequently accompanied by juvenile cataract, saddle nose, congenital bone defects, disturbances of hair growth, hypogonadism, and an increased risk of osteosarcoma in childhood and skin cancer later in life.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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