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Mouse Anti-RECQL4 Recombinant Antibody (2G8) (CBMAB-R2018-CN)

This product is a Mouse antibody that recognizes RECQL4. The antibody 2G8 can be used for immunoassay techniques such as: ELISA, IHC.
See all RECQL4 antibodies
Published Data
Fig. 1 Immunohistochemical staining of RECQL4.
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Fig. 2 IHC staining shows localization of RECQ helicases in CRC.
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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
2G8
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC

Basic Information

Immunogen
Full-length recombinant protein corresponding to aa. 1-652 from human RECQL4 (H13277) with GST tag
Specificity
Human, Mouse
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
RecQ protein-like 4
Introduction
The protein encoded by this gene is a DNA helicase that belongs to the RecQ helicase family. DNA helicases unwind double-stranded DNA into single-stranded DNAs and may modulate chromosome segregation. This gene is predominantly expressed in thymus and testis. Mutations in this gene are associated with Rothmund-Thomson, RAPADILINO and Baller-Gerold syndromes. [provided by RefSeq, Jan 2010]
Entrez Gene ID
Human9401
Mouse79456
UniProt ID
HumanO94761
MouseQ75NR7
Alternative Names
RecQ Like Helicase 4; RecQ Helicase-Like 4; RecQ Protein-Like 4; RECQ4; DNA Helicase, RecQ-Like, Type 4; DNA Helicase, RecQ-Like Type 4; ATP-Dependent DNA Helicase Q4; EC 3.6.4.12; RTS;
Function
DNA-dependent ATPase. May modulate chromosome segregation.
Biological Process
Biological Process DNA duplex unwindingManual Assertion Based On ExperimentIDA:GO_Central
Biological Process DNA recombinationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process DNA repairManual Assertion Based On ExperimentIBA:GO_Central
Biological Process DNA replicationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process DNA unwinding involved in DNA replicationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process telomere maintenanceManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process telomeric D-loop disassemblyManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
Cytoplasm
Nucleus
Involvement in disease
RAPADILINO syndrome (RAPADILINOS):
Disease characterized by radial and patellar aplasia or hypoplasia.
Baller-Gerold syndrome (BGS):
An autosomal recessive syndrome characterized by short stature, craniosynostosis, absent or hypoplastic radii, short and curved ulna, fused carpal bones and absent carpals, metacarpals and phalanges. Some patients manifest poikiloderma. Cases reported as Baller-Gerold syndrome have phenotypic overlap with several other disorders, including Saethre-Chotzen syndrome.
Rothmund-Thomson syndrome 2 (RTS2):
An autosomal recessive disorder characterized by dermatological features such as skin atrophy, pigmentation abnormalities, and telangiectasia. It is frequently accompanied by juvenile cataract, saddle nose, congenital bone defects, disturbances of hair growth, hypogonadism, and an increased risk of osteosarcoma in childhood and skin cancer later in life.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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