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Mouse Anti-REEP2 Recombinant Antibody (2B7) (CBMAB-R2022-CN)

This product is a Mouse antibody that recognizes REEP2. The antibody 2B7 can be used for immunoassay techniques such as: WB, FC.
See all REEP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Dog, Rat, Mouse
Clone
2B7
Antibody Isotype
IgG2a
Application
WB, FC

Basic Information

Immunogen
Full length human recombinant protein of human REEP2 (NP_0557690) produced in HEK293T cell
Specificity
Human, Dog, Rat, Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium azide
Concentration
1.16 mg/mL

Target

Full Name
Receptor Accessory Protein 2
Introduction
This gene encodes a member of the receptor expression enhancing protein family. Studies of a related gene in mouse suggest that the encoded protein is found in the cell membrane and enhances the function of sweet taste receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Entrez Gene ID
Human51308
Mouse225362
Rat682105
Dog100683708
UniProt ID
HumanQ9BRK0
MouseQ8VCD6
RatM0R8C1
DogE2RFM8
Alternative Names
Receptor Accessory Protein 2; SGC32445; C5orf19; Receptor Expression-Enhancing Protein 2; Chromosome 5 Open Reading Frame 19; SPG72; Yip2d;
Function
Required for endoplasmic reticulum (ER) network formation, shaping and remodeling. May enhance the cell surface expression of odorant receptors (By similarity).
Biological Process
Biological Process endoplasmic reticulum tubular network organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein transport into membrane raftIEA:Ensembl
Biological Process regulation of intracellular transportIEA:Ensembl
Biological Process sensory perception of bitter tasteIEA:Ensembl
Biological Process sensory perception of sweet tasteIEA:Ensembl
Cellular Location
Membrane
Involvement in disease
Spastic paraplegia 72 (SPG72):
A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG72 is a pure form of spastic paraplegia with onset of difficulty walking and stiff legs associated with hyperreflexia and extensor plantar responses in early childhood. Some patients may have pes cavus or sphincter disturbances. Cognition, speech, and ocular function are normal. SPG72 inheritance is autosomal dominant or recessive.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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