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Rabbit Anti-REG3A Recombinant Antibody (019) (CBMAB-R2061-CN)

This product is a Rabbit antibody that recognizes REG3A. The antibody 019 can be used for immunoassay techniques such as: ELISA, IHC-P.
See all REG3A antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
019
Antibody Isotype
IgG
Application
ELISA, IHC-P

Basic Information

Immunogen
Recombinant Human REG3A protein
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
regenerating islet-derived 3 alpha
Introduction
This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Nov 2014]
Entrez Gene ID
5068
UniProt ID
Q06141
Alternative Names
Regenerating Family Member 3 Alpha; Regenerating Islet-Derived Protein III-Alpha; Hepatointestinal Pancreatic Protein; Regenerating Islet-Derived 3 Alpha; Pancreatitis-Associated Protein 1; Human Proislet Peptide; Reg III-Alpha; REG-3-Alpha; HIP/PAP; PAP1; PAP; HIP; Regenerating Islet-Derived Protein 3-Alpha;
Function
Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway.
Biological Process
Biological Process acute-phase responseIEA:UniProtKB-KW
Biological Process antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell wall disruption in another organismManual Assertion Based On ExperimentIBA:GO_Central
Biological Process heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of keratinocyte differentiationISS:UniProtKB
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of keratinocyte proliferationISS:UniProtKB
Biological Process positive regulation of wound healingISS:UniProtKB
Biological Process response to peptide hormoneManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
Found in the apical region of pancreatic acinar cells.
PTM
Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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