Mouse Anti-REG3A Recombinant Antibody (15j178) (CBMAB-R2063-CN)

Name: Mouse Anti-REG3A Recombinant Antibody (15j178)
SKU: CBMAB-R2063-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

15j178

Application

ELISA, ICC, IHC, WB

Immunogen

Recombinant REG3a (Cys40-Asn164) expressed in E. coli

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2, 50% Glycerol

Preservative

0.02% Sodium azide

Concentration

0.5 mg/mL

More Infomation

Target

Full Name

regenerating islet-derived 3 alpha

Introduction

This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Nov 2014]

Entrez Gene ID

5068

UniProt ID

Q06141

Alternative Names

Regenerating Family Member 3 Alpha; Regenerating Islet-Derived Protein III-Alpha; Hepatointestinal Pancreatic Protein; Regenerating Islet-Derived 3 Alpha; Pancreatitis-Associated Protein 1; Human Proislet Peptide; Reg III-Alpha; REG-3-Alpha; HIP/PAP; PAP1; PAP; HIP; Regenerating Islet-Derived Protein 3-Alpha;

Function

Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway.

Biological Process

Biological Process acute-phase responseIEA:UniProtKB-KW
Biological Process antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell wall disruption in another organismManual Assertion Based On ExperimentIBA:GO_Central
Biological Process heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of keratinocyte differentiationISS:UniProtKB
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of keratinocyte proliferationISS:UniProtKB
Biological Process positive regulation of wound healingISS:UniProtKB
Biological Process response to peptide hormoneManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Secreted
Found in the apical region of pancreatic acinar cells.

PTM

Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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