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Rabbit Anti-RETREG1 Recombinant Antibody (CBXF-1076) (CBMAB-F0788-CQ)

This product is a rabbit antibody that recognizes FAM134B. The antibody CBXF-1076 can be used for immunoassay techniques such as: WB.
See all RETREG1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBXF-1076
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Reticulophagy Regulator 1
Introduction
The protein encoded by this gene is a cis-Golgi transmembrane protein that may be necessary for the long-term survival of nociceptive and autonomic ganglion neurons. Mutations in this gene are a cause of hereditary sensory and autonomic neuropathy type IIB (HSAN IIB), and this gene may also play a role in susceptibility to vascular dementia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Entrez Gene ID
Human54463
Mouse66270
Rat619558
UniProt ID
HumanQ9H6L5
MouseQ8VE91
RatQ5FVM3
Alternative Names
Family With Sequence Similarity 134 Member B; Family With Sequence Similarity 134, Member B; Protein FAM134B; JK-1; JK1
Function
Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes (PubMed:26040720).
Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins (PubMed:26040720).
Required for long-term survival of nociceptive and autonomic ganglion neurons (PubMed:19838196, PubMed:26040720).
Biological Process
Biological Process collagen catabolic processIEA:Ensembl
Biological Process endoplasmic reticulum organizationIEA:Ensembl
Biological Process mitophagyIEA:Ensembl
Biological Process negative regulation of neuron apoptotic processManual Assertion Based On ExperimentIMP:GO_Central
Biological Process reticulophagyManual Assertion Based On ExperimentIMP:GO_Central
Biological Process sensory perception of painManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process white fat cell differentiationIEA:Ensembl
Cellular Location
Golgi apparatus, cis-Golgi network membrane
Endoplasmic reticulum membrane
Involvement in disease
Neuropathy, hereditary sensory and autonomic, 2B (HSAN2B):
A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN2B is an autosomal recessive disorder characterized by impairment of pain, temperature and touch sensation. Onset occurs in the first or second decade, with impaired nociception and progressive mutilating ulceration of the hands and feet with osteomyelitis and acroosteolysis. Amputations of the hands and feet are common. Autonomic dysfunction includes hyperhidrosis, urinary incontinence, and slow pupillary light response.
Topology
Cytoplasmic: 1-59
Helical: 60-80
Lumenal: 81-95
Helical: 96-116
Cytoplasmic: 117-118
Helical: 119-139
Lumenal: 140-208
Helical: 209-229
Cytoplasmic: 230-497
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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