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Mouse Anti-RFC1 Recombinant Antibody (3F8) (CBMAB-R2313-CN)

This product is a Mouse antibody that recognizes RFC1. The antibody 3F8 can be used for immunoassay techniques such as: ELISA, WB.
See all RFC1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3F8
Antibody Isotype
IgG3, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa. 1-110, from human RFC1 (H51786) with GST tag
Specificity
Human
Antibody Isotype
IgG3, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
Replication Factor C Subunit 1
Introduction
This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011]
Entrez Gene ID
5981
UniProt ID
P35251
Alternative Names
Replication Factor C Subunit 1; Replication Factor C (Activator 1) 1, 145kDa; Replication Factor C 140 KDa Subunit; Replication Factor C Large Subunit; Activator 1 140 KDa Subunit; Activator 1 Large Subunit; DNA-Binding Protein PO-GA; Activator 1 Subunit 1; RF-C 140 KDa Subunit; A1 140 KDa Subunit;
Function
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA.1 Publication
Interacts with C-terminus of PCNA. 5' phosphate residue is required for binding of the N-terminal DNA-binding domain to duplex DNA, suggesting a role in recognition of non-primer template DNA structures during replication and/or repair.
Biological Process
Biological Process DNA clamp unloadingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process DNA repairIEA:InterPro
Biological Process DNA-templated DNA replicationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Biological Process positive regulation of transcription, DNA-templatedIEA:Ensembl
Biological Process telomere maintenance via telomeraseManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus
Involvement in disease
Cerebellar ataxia, neuropathy, and vestibular areflexia syndrome (CANVAS):
An autosomal recessive neurologic disease characterized by imbalance, cerebellar ataxia, impaired vestibular function, and non-length-dependent sensory deficit.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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