Mouse Anti-RFC5 Recombinant Antibody (1B1) (CBMAB-R2337-CN)

Name: Mouse Anti-RFC5 Recombinant Antibody (1B1)
SKU: CBMAB-R2337-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1B1

Application

ELISA, WB

Immunogen

Full length recombinant corresponding to human RFC5, aa. 1-341 (H13961) with GST tag

Specificity

Human

Antibody Isotype

IgG2a, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

More Infomation

Target

Full Name

replication factor C (activator 1) 5, 36.5kDa

Introduction

This gene encodes the smallest subunit of the replication factor C complex, which consists of five distinct subunits (140, 40, 38, 37, and 36 kDa) and is required for DNA replication. This subunit interacts with the C-terminal region of proliferating cell nuclear antigen and is required to open and load proliferating cell nuclear antigen onto DNA during S phase. It is a member of the AAA+ (ATPases associated with various cellular activities) ATPase family and forms a core complex with the 38 and 40 kDa subunits that possesses DNA-dependent ATPase activity. A related pseudogene has been identified on chromosome 9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]

Entrez Gene ID

5985

UniProt ID

P40937

Alternative Names

Replication Factor C Subunit 5; Replication Factor C (Activator 1) 5, 36.5kDa; RF-C 36 KDa Subunit; A1 36 KDa Subunit; RFC36; Replication Factor C (Activator 1) 5 (36.5kD);

Function

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.

Biological Process

Biological Process DNA duplex unwindingIEA:GOC
Biological Process DNA repairManual Assertion Based On ExperimentIBA:GO_Central
Biological Process DNA replication1 PublicationNAS:UniProtKB
Biological Process DNA-templated DNA replicationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of DNA-directed DNA polymerase activityManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Nucleus

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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