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Mouse Anti-RFX5 Monoclonal Antibody (1D11) (CBMAB-0043-LY)

This product is mouse monoclonal antibody recognizes RFX5 of human. The antibody 1D11 immunoassay techniques such as: IP, MA, WB.
See all RFX5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1D11
Antibody Isotype
IgG1
Application
IP, MA, WB

Basic Information

Immunogen
Recombinant peptide (Protein Domain)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
regulatory factor X, 5 (influences HLA class II expression)
Introduction
The gene is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain. This domain is called the RFX motif. Multiple alternatively spliced transcript variants have been found and the full-length natures of two of them have been determined.
Entrez Gene ID
5993
UniProt ID
P48382
Function
Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters.
Biological Process
Biological Process negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Biological Process positive regulation of MHC class II biosynthetic process1 PublicationIC:ComplexPortal
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Involvement in disease
Bare lymphocyte syndrome 2 (BLS2):
A severe combined immunodeficiency disease with early onset. It is characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. The consequence include extreme susceptibility to viral, bacterial and fungal infections.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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